2,4-Dichloro-5-fluoropyrimidine → 2,5-Dichloro-4-methylpyrimidine

HRID 243860Notes

Reaction equation

HRID 243860 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([CH3:8])[C:5](F)=[CH:4][N:3]=1.[Cl:10]C1N=C(Cl)C(F)=CN=1>>[Cl:1][C:2]1[N:7]=[C:6]([CH3:8])[C:5]([Cl:10])=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 2507052,4-Dichloro-5-fluoropyrimidineHCID 207780732-Chloro-5-fluoro-4-methylpyrimidine

Product 1

HCID 212786212,5-Dichloro-4-methylpyrimidine

Procedure

The title compound was prepared in a manner analogous to Intermediate 55, substituting 2,4,5-trichloropyrimidine for 2,4-dichloro-5-fluoropyrimidine. 1H NMR (500 MHz, CDCl3): 8.47 (s, 1H), 2.61 (s, 3H).

Sources & evidence

ORD record
ord-ec7dfcbe26d74f6f9ff5637ceffc174d
Source dataset
uspto-grants-2014_02
Patent number
US08653263B2

Reaction notes

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