HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,4-Dichloro-5-fluoropyrimidine → 2-Chloro-5-fluoro-4,6-dimethylpyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,4-Dichloro-5-fluoropyrimidine | HCID 250705 | — |
| Reactant | 2-Chloro-5-fluoro-4-methylpyrimidine | HCID 20778073 | — |
| Product | 2-Chloro-5-fluoro-4,6-dimethylpyrimidine | HCID 86668839 | — |
Reaction Steps
2-Chloro-5-fluoro-4,6-dimethylpyrimidine was prepared in a manner analogous to Intermediate 55, substituting 2,4,6-trichloro-5-fluoropyrimidine for 2,4-dichloro-5-fluoropyrimidine. 1H NMR (500 MHz, CDCl3): 2.50 (d, J=2.7 Hz, 6H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08653263B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-6bd54134d84542b9bd82e01df14fd3c9 |
| Source note | uspto-grants-2014_02 |