HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-6-methylnicotinic acid → 4-(1H-1,2,3-Triazol-1-yl)nicotinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-6-methylnicotinic acid | HCID 121724 | — |
| Reactant | 4-Chloronicotinic acid | HCID 818229 | — |
| Reactant | 6-Methyl-2-[1,2,3]triazol-2-yl-nicotinic acid | HCID 67086855 | — |
| Product | 4-(1H-1,2,3-Triazol-1-yl)nicotinic acid | HCID 67086995 | — |
Reaction Steps
The title compound was prepared in a manner analogous to Intermediate 70 substituting 4-chloronicotinic acid for 2-chloro-6-methylnicotinic acid. MS (ESI): mass calculated for C11H10N4O3, 246.22; m/z found 247.3 [M+H]+. 1H NMR (400 MHz, CD3OD): 8.09 (t, J=2.8 Hz, 1H), 7.92-7.86 (m, 3H), 7.66 (dd, J=8.7, 3.3 Hz, 1H), 2.17 (dd, J=2.5, 1.3 Hz, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08653263B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-054d2835cdcf4e23818a1dde12a36f61 |
| Source note | uspto-grants-2014_02 |