HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 24390Generated: October 25, 2026
Piperidine → N-[3-(2,2-dimethylchroman-6-ylmethylene)-2-oxo-2,3-dihydro-1H-indol-6-yl]acetamide
https://huagongshe.com/reaction/24390
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-6-carbaldehyde | HCID 1797751 | — |
| Reactant | N-(2-Oxoindolin-6-yl)acetamide | HCID 2749839 | — |
| Solvent | Water | HCID 962 | — |
| Product | N-[3-(2,2-dimethylchroman-6-ylmethylene)-2-oxo-2,3-dihydro-1H-indol-6-yl]acetamide | HCID 57040241 | 44.2% |
Reaction Steps
A mixture of 6-acetamido-2-oxindole (285 mg), 2,2-dimethylchroman-6-carboxaldehyde (285 mg) and piperidine (0.2 ml) was stirred at 90° C. overnight. The reaction mixture was cooled and diluted with 20 ml of water. The sticky solid which formed was filtered and chromatographed (2% ethanol in ethyl acetate) to give 240 mg (44%) of N-[3-(2,2-dimethylchroman-6-ylmethylene)-2-oxo-2,3-dihydro-1H-indol-6-yl]acetamide as an orange red solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06855730B2 |
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| Source dataset | uspto-grants-2005_02 |
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| ORD ID | ord-01a3a2ad64bf410eb46cf49e157ea541 |
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| Source note | uspto-grants-2005_02 |
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