HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Pyridin-2-YL)benzoic acid → 2-(4,6-Dimethoxypyrimidin-2-yl)-5-[(2-pyridin-2-ylphenyl)carbonyl]octahydro-pyrrolo[3,4-c]pyrrole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Pyridin-2-YL)benzoic acid | HCID 15733175 | — |
| Reactant | 2-(4,6-Dimethoxy-pyrimidin-2-yl)-octahydro-pyrrolo[3,4-c]pyrrole | HCID 67116491 | — |
| Product | 2-(4,6-Dimethoxypyrimidin-2-yl)-5-[(2-pyridin-2-ylphenyl)carbonyl]octahydro-pyrrolo[3,4-c]pyrrole | HCID 52917463 | — |
Reaction Steps
The title compound was prepared in a manner analogous to Example 15 utilizing Intermediate 39 and 2-pyridin-2-yl-benzoic acid. MS (ESI) mass calcd. for C24H25N5O3, 431.49; m/z found, 432.2 [M+H]+. 1H NMR (CDCl3): 8.49 (d, J=3.9 Hz, 1H), 7.69-7.49 (m, 3H), 7.48-7.29 (m, 3H), 7.15-7.04 (m, 1H), 5.32 (s, 1H), 3.92-3.61 (m, 8H), 3.60-3.40 (m, 2H), 3.35-3.15 (m, 3H), 2.98-2.65 (m, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08653263B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-01e39d079e8d40a88e79591bc5e916e1 |
| Source note | uspto-grants-2014_02 |