2-(Hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-quinoxaline → HCID 178519506, compound

HRID 243944Notes

Reaction equation

HRID 243944 reaction equation
[CH2:1]1[CH:5]2[CH2:6][NH:7][CH2:8][CH:4]2[CH2:3][N:2]1[C:9]1[CH:18]=[N:17][C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]=1.[N:19]1[N:20]=[C:21]([C:24]2[CH:32]=[CH:31][CH:30]=[CH:29][C:25]=2[C:26](O)=[O:27])[NH:22][CH:23]=1>>[N:19]1[N:20]=[C:21]([C:24]2[CH:32]=[CH:31][CH:30]=[CH:29][C:25]=2[C:26]([N:7]2[CH2:6][CH:5]3[CH2:1][N:2]([C:9]4[CH:18]=[N:17][C:16]5[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=5)[N:10]=4)[CH2:3][CH:4]3[CH2:8]2)=[O:27])[NH:22][CH:23]=1

Participants

3

Reactant 2

HCID 610372812-(Hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-quinoxalineHCID 178524291HCID 178524291, compound

Product 1

HCID 178519506HCID 178519506, compound

Procedure

The title compound was prepared in a manner analogous to Example 15 utilizing Intermediate 35 and 2-(4H-[1,2,4]triazol-3-yl)-benzoic acid. MS (ESI) mass calcd. for C23H21N7O, 411.47; m/z found, 412.2 [M+H]+. 1H NMR (CDCl3): 8.28 (s, 1H), 8.11 (d, J=8.1 Hz, 1H), 8.01 (br s, 1H), 7.89 (dd, J=8.2, 1.2 Hz, 1H), 7.69 (dd, J=8.4, 1.0 Hz, 1H), 7.59 (ddd, J=8.4, 7.0, 1.4 Hz, 1H), 7.55-7.43 (m, 2H), 7.42-7.33 (m, 2H), 3.89-4.00 (m, 2H), 3.82-3.72 (m, 2H), 3.71-3.64 (m, 1H), 3.55-3.42 (m, 2H), 3.20-2.98 (m, 3H).

Sources & evidence

ORD record
ord-5ca00580c80343be94b8d39f6b83ac2d
Source dataset
uspto-grants-2014_02
Patent number
US08653263B2

Reaction notes

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