5-fluoro-2-(2H-1,2,3-triazol-2-yl)benzoic acid → 4-[5-{[5-Fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]carbonyl}hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl]-N, N-dimethyl-6-(trifluoromethyl)pyrimidin-2-amine

Participants

Role	Name	HCID	Charge
Reactant	5-fluoro-2-(2H-1,2,3-triazol-2-yl)benzoic acid	HCID 67086948	—
Reactant	[4-(Hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-6-trifluoromethyl-pyrimidin-2-yl]-dimethyl-amine	HCID 67116323	—
Product	4-[5-{[5-Fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]carbonyl}hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl]-N, N-dimethyl-6-(trifluoromethyl)pyrimidin-2-amine	HCID 67116412	—

Reaction Steps

The title compound was prepared in a manner analogous to Example 15 utilizing Intermediate 36 and Intermediate 1. MS (ESI): mass calculated for C22H22F4N8O, 490.46; m/z found 490.9 [M+H]+. 1H NMR (400 MHz, CDCl3): 8.00-7.92 (m, 1H), 7.78-7.64 (m, 2H), 7.26-7.20 (m, 1H), 7.17-7.11 (m, 1H), 5.87 (br s, 1H), 3.96-2.87 (m, 16H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08653263B2
Source dataset	uspto-grants-2014_02
ORD ID	ord-2522bc289359466b89cbe55d7334afc9
Source note	uspto-grants-2014_02