4-fluoro-2-(2H-1,2,3-triazol-2-yl)benzoic acid → HCID 67116177, compound

HRID 243954Notes

Reaction equation

HRID 243954 reaction equation
[CH2:1]1[CH:5]2[CH2:6][NH:7][CH2:8][CH:4]2[CH2:3][N:2]1[C:9]1[CH:14]=[C:13]([C:15]([F:18])([F:17])[F:16])[N:12]=[C:11]([N:19]([CH3:21])[CH3:20])[N:10]=1.[F:22][C:23]1[CH:31]=[CH:30][C:26]([C:27](O)=[O:28])=[C:25]([N:32]2[N:36]=[CH:35][CH:34]=[N:33]2)[CH:24]=1>>[CH3:20][N:19]([CH3:21])[C:11]1[N:10]=[C:9]([N:2]2[CH2:3][CH:4]3[CH2:8][N:7]([C:27]([C:26]4[CH:30]=[CH:31][C:23]([F:22])=[CH:24][C:25]=4[N:32]4[N:36]=[CH:35][CH:34]=[N:33]4)=[O:28])[CH2:6][CH:5]3[CH2:1]2)[CH:14]=[C:13]([C:15]([F:18])([F:17])[F:16])[N:12]=1

Participants

3

Reactant 2

HCID 670868864-fluoro-2-(2H-1,2,3-triazol-2-yl)benzoic acidHCID 67116323[4-(Hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-6-trifluoromethyl-pyrimidin-2-yl]-dimethyl-amine

Product 1

HCID 67116177HCID 67116177, compound

Procedure

The title compound was prepared in a manner analogous to Example 15 utilizing Intermediate 36 and Intermediate 4. MS (ESI): mass calculated for C22H22F4N8O, 490.46; m/z found 490.9 [M+H]+. 1H NMR (400 MHz, CDCl3): 7.84-7.64 (m, 3H), 7.45-7.36 (m, 1H), 7.20-7.07 (m, 1H), 5.87 (br s, 1H), 4.04-2.79 (m, 16H).

Sources & evidence

ORD record
ord-e8a2ac5f183a44ee82e65fc9fac5f8eb
Source dataset
uspto-grants-2014_02
Patent number
US08653263B2

Reaction notes

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