2-Chloro-5-methoxypyridine → HCID 67116681, compound

HRID 243960Notes

Reaction equation

HRID 243960 reaction equation
[CH2:1]1[CH:5]2[CH2:6][NH:7][CH2:8][CH:4]2[CH2:3][N:2]1[C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[C:17]1[S:18][CH:19]=[CH:20][CH:21]=1)=[O:10].Cl[C:23]1[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][N:24]=1>>[CH3:30][O:29][C:26]1[CH:27]=[CH:28][C:23]([N:7]2[CH2:8][CH:4]3[CH:5]([CH2:1][N:2]([C:9]([C:11]4[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=4[C:17]4[S:18][CH:19]=[CH:20][CH:21]=4)=[O:10])[CH2:3]3)[CH2:6]2)=[N:24][CH:25]=1

Participants

3

Reactant 2

HCID 151690002-Chloro-5-methoxypyridineHCID 67116155(Hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-(2-thiophen-2-yl-phenyl)-methanone

Product 1

HCID 67116681HCID 67116681, compound

Procedure

The title compound was prepared in a manner analogous to Example 15 utilizing Intermediate 37 and 2-chloro-5-methoxy-pyridine. MS (ESI): mass calculated for C23H23N3O2S, 405.52; m/z found 406.2 [M+H]+. 1H NMR (400 MHz, CDCl3): 7.88 (d, J=2.7, 1H), 7.54-7.47 (m, 1H), 7.45-7.31 (m, 4H), 7.25-7.19 (m, 1H), 7.18-7.12 (m, 1H), 7.06-6.88 (m, 1H), 6.30-6.13 (m, 1H), 3.94-2.47 (m, 13H).

Sources & evidence

ORD record
ord-88e6e8c57ab043f3afae37992e2147d9
Source dataset
uspto-grants-2014_02
Patent number
US08653263B2

Reaction notes

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