2-Chlorobenzoxazole → HCID 67116330, compound

HRID 243967Notes

Reaction equation

HRID 243967 reaction equation
[CH2:1]1[CH:5]2[CH2:6][NH:7][CH2:8][CH:4]2[CH2:3][N:2]1[C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[C:17]1[S:18][CH:19]=[CH:20][CH:21]=1)=[O:10].Cl[C:23]1[O:24][C:25]2[CH:31]=[CH:30][CH:29]=[CH:28][C:26]=2[N:27]=1>>[S:18]1[CH:19]=[CH:20][CH:21]=[C:17]1[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=1[C:9]([N:2]1[CH2:3][CH:4]2[CH2:8][N:7]([C:23]3[O:24][C:25]4[CH:31]=[CH:30][CH:29]=[CH:28][C:26]=4[N:27]=3)[CH2:6][CH:5]2[CH2:1]1)=[O:10]

Participants

3

Reactant 2

HCID 119862-ChlorobenzoxazoleHCID 67116155(Hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-(2-thiophen-2-yl-phenyl)-methanone

Product 1

HCID 67116330HCID 67116330, compound

Procedure

The title compound was prepared in a manner analogous to Example 15 utilizing Intermediate 37 and 2-chloro-benzooxazole. MS (ESI): mass calculated for C24H21N3O2S, 415.52; m/z found 416.1 [M+H]+. 1H NMR (400 MHz, CDCl3): 7.83-6.68 (m, 11H), 4.20-2.47 (m, 10H).

Sources & evidence

ORD record
ord-d1928b4e014a4e9097044c87160c48c0
Source dataset
uspto-grants-2014_02
Patent number
US08653263B2

Reaction notes

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