3-phenylpyridine-2-carboxylic Acid → [5-(4,6-Dimethoxy-pyrimidin-2-yl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-(3-phenyl-pyridin-2-yl)-methanone

HRID 244005Notes

Reaction equation

HRID 244005 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[N:6]=[C:5]([N:11]2[CH2:18][CH:17]3[CH:13]([CH2:14][NH:15][CH2:16]3)[CH2:12]2)[N:4]=1.[C:19]1([C:25]2[C:26]([C:31](O)=[O:32])=[N:27][CH:28]=[CH:29][CH:30]=2)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[N:6]=[C:5]([N:11]2[CH2:18][CH:17]3[CH2:16][N:15]([C:31]([C:26]4[C:25]([C:19]5[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=5)=[CH:30][CH:29]=[CH:28][N:27]=4)=[O:32])[CH2:14][CH:13]3[CH2:12]2)[N:4]=1

Participants

3

Reactant 2

HCID 27627893-phenylpyridine-2-carboxylic AcidHCID 671164912-(4,6-Dimethoxy-pyrimidin-2-yl)-octahydro-pyrrolo[3,4-c]pyrrole

Product 1

HCID 69938950[5-(4,6-Dimethoxy-pyrimidin-2-yl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-(3-phenyl-pyridin-2-yl)-methanone

Procedure

The title compound was prepared in a manner analogous to Example 15 utilizing Intermediate 39 and 3-phenyl-pyridine-2-carboxylic acid. MS (ESI): mass calculated for C24H25N5O3, 431.50; m/z found 432.3 [M+H]+.

Sources & evidence

ORD record
ord-f302bc06c80a42179a4e9c3778693d86
Source dataset
uspto-grants-2014_02
Patent number
US08653263B2

Reaction notes

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