反应详情

Zinc dust (6.5 g) was added to a solution of 3,3-dibromo-7-azaoxindole (2.9 g) in acetic acid (20 ml) and acetonitrile (30 ml). The mixture was stirred for 2 hours at room temperature. The solids were removed by filtration and the solvent evaporated. The residue was treated with ethyl acetate. The ethyl acetate solution containing insoluble solid was passed through a short column of silica gel. The collected ethyl acetate solution was evaporated and the residue dried under vacuum to give 1.8 g (91% yield) of 7-aza-2-oxindole acetic acid salt.

1. customThe solids were removed by filtration
2. customthe solvent evaporated
3. additionThe residue was treated with ethyl acetate
4. additionThe ethyl acetate solution containing insoluble solid
5. customThe collected ethyl acetate solution was evaporated
6. customthe residue dried under vacuum