HCID 66211834, compound → HCID 67116336, compound

HRID 244024Notes

Reaction equation

HRID 244024 reaction equation
[N+:1]([C:4]1[CH:5]=[N:6][C:7]([N:10]2[CH2:17][CH:16]3[CH:12]([CH2:13][NH:14][CH2:15]3)[CH2:11]2)=[N:8][CH:9]=1)([O-:3])=[O:2].[F:18][C:19]1[CH:27]=[CH:26][CH:25]=[C:24]([N:28]2[N:32]=[CH:31][CH:30]=[N:29]2)[C:20]=1[C:21](O)=[O:22]>>[F:18][C:19]1[CH:27]=[CH:26][CH:25]=[C:24]([N:28]2[N:32]=[CH:31][CH:30]=[N:29]2)[C:20]=1[C:21]([N:14]1[CH2:13][CH:12]2[CH:16]([CH2:17][N:10]([C:7]3[N:8]=[CH:9][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][N:6]=3)[CH2:11]2)[CH2:15]1)=[O:22]

Participants

3

Reactant 2

HCID 66211834HCID 66211834, compoundHCID 670866272-Fluoro-6-(2H-1,2,3-triazol-2-yl)benzoic acid

Product 1

HCID 67116336HCID 67116336, compound

Procedure

The title compound was prepared in a manner analogous to Example 15, utilizing Intermediate 46 and Intermediate 12. MS (ESI): mass calculated for C19H17FN8O3, 424.14; m/z found 425.2 [M+H]+. 1H NMR (400 MHz, CDCl3): 9.10 (ddd, J=9.9, 5.7, 3.3, 2H), 7.90-7.79 (m, 2H), 7.74 (d, J=6.6, 1H), 7.55-7.44 (m, 1H), 7.22-7.10 (m, 1H), 4.13-3.60 (m, 7H), 3.40-3.07 (m, 3H).

Sources & evidence

ORD record
ord-7256b5e4cb2844b8b6259ea9a7d2f4ad
Source dataset
uspto-grants-2014_02
Patent number
US08653263B2

Reaction notes

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