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HRID 244026作成日：2026年10月25日

2-Methoxy-4-methylbenzoic acid → (5-(4,6-Dimethylpyrimidin-2-yl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)(2-methoxy-4-methylphenyl)methanone

https://huagongshe.com/reaction/244026

反応式

関与物質

役割名称HCID仕込み量
反応物2-Methoxy-4-methylbenzoic acidHCID 597164—
反応物2-(4,6-Dimethylpyrimidin-2-yl)octahydropyrrolo[3,4-c]pyrroleHCID 66210875—
生成物(5-(4,6-Dimethylpyrimidin-2-yl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)(2-methoxy-4-methylphenyl)methanoneHCID 67116335—

反応手順

The title compound was prepared in a manner analogous to Example 15, utilizing Intermediate 23 and 2-methoxy-4-methylbenzoic acid. MS (ESI): mass calculated for C21H26N4O2, 366.21; m/z found 367.3 [M+H]+. 1H NMR (400 MHz, CDCl3): 7.13 (d, J=7.6, 1H), 6.77 (d, J=7.6, 1H), 6.70 (s, 1H), 6.28 (s, 1H), 4.00-3.40 (m, 11H), 3.27-2.85 (m, 3H), 2.41-2.19 (m, 9H).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08653263B2
出典データセットuspto-grants-2014_02
ORD IDord-4948e3e8218a4275b4791c32582e17e3
出典メモuspto-grants-2014_02