2-{[2-Fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl]carbonyl}-5-(4-methyl-1,3,5-triazin-2-yl)octahydropyrrolo[3,4-c]pyrrole → HCID 178519509, compound

HRID 244040Notes

Reaction equation

HRID 244040 reaction equation
[N:1]1[N:2]=[C:3]([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[C:12]([N:14]2[CH2:18][CH:17]3[CH2:19][N:20](C(OC(C)(C)C)=O)[CH2:21][CH:16]3[CH2:15]2)=[O:13])[NH:4][CH:5]=1.FC1C=CC=C(N2N=CC=N2)C=1C(N1CC2C(CN(C3N=C(C)N=CN=3)C2)C1)=O>>[N:1]1[N:2]=[C:3]([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[C:12]([N:14]2[CH2:15][CH:16]3[CH:17]([CH2:19][NH:20][CH2:21]3)[CH2:18]2)=[O:13])[NH:4][CH:5]=1

Participants

3

Reactant 2

HCID 671162092-{[2-Fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl]carbonyl}-5-(4-methyl-1,3,5-triazin-2-yl)octahydropyrrolo[3,4-c]pyrroleHCID 178451519HCID 178451519, compound

Product 1

HCID 178519509HCID 178519509, compound

Procedure

(2-(4H-1,2,4-Triazol-3-yl)phenyl)(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)methanone was prepared in a manner analogous to Example 303, substituting Intermediate 59 for the product of Example 303 in Step C. MS (ESI) mass calculated for C15H17NO, 283.14; m/z found, 284.2.

Sources & evidence

ORD record
ord-7af32665b21c4426841d8ae662ad5f3b
Source dataset
uspto-grants-2014_02
Patent number
US08653263B2

Reaction notes

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