HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl octahydropyrrolo(3,4-c)pyrrole-2-carboxylate → 2-(4,6-Dimethylpyrimidin-2-yl)-5-{[2-fluoro-6-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl]carbonyl}octahydropyrrolo[3,4-c]pyrrole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl octahydropyrrolo(3,4-c)pyrrole-2-carboxylate | HCID 4142526 | — |
| Reactant | 2-(4,6-Dimethylpyrimidin-2-yl)octahydropyrrolo[3,4-c]pyrrole | HCID 66210875 | — |
| Reactant | 2-Fluoro-6-(3-methyl-1,2,4-oxadiazol-5-yl)benzoic acid | HCID 67086832 | — |
| Reactant | HCID 178451519 | HCID 178451519 | — |
| Reactant | HCID 178524291 | HCID 178524291 | — |
| Product | 2-(4,6-Dimethylpyrimidin-2-yl)-5-{[2-fluoro-6-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl]carbonyl}octahydropyrrolo[3,4-c]pyrrole | HCID 67116830 | — |
Reaction Steps
The title compound was prepared in a manner analogous to Intermediate 59 substituting Intermediate 23 for Intermediate 15 and Intermediate 64 for 2-(4H-[1,2,4]triazol-3-yl)-benzoic acid. MS (ESI) mass calculated for C22H23FN6O2, 422.19; m/z found, 423.2. 1H NMR (500 MHz, CDCl3): 7.96-7.86 (m, 1H), 7.55-7.47 (m, 1H), 7.38-7.29 (m, 1H), 6.32-6.23 (m, 1H), 3.99-3.46 (m, 7H), 3.27-2.95 (m, 3H), 2.49-2.37 (m, 3H), 2.36-2.21 (m, 6H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08653263B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-eb7cb7179af5414cab9b5ff3541da1d6 |
| Source note | uspto-grants-2014_02 |