2,6-Dimethoxybenzoic Acid → HCID 67116470, compound

HRID 244046Notes

Reaction equation

HRID 244046 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([N:9]2[CH2:16][CH:15]3[CH:11]([CH2:12][NH:13][CH2:14]3)[CH2:10]2)[N:3]=1.[CH3:17][O:18][C:19]1[CH:27]=[CH:26][CH:25]=[C:24]([O:28][CH3:29])[C:20]=1[C:21](O)=[O:22]>>[CH3:29][O:28][C:24]1[CH:25]=[CH:26][CH:27]=[C:19]([O:18][CH3:17])[C:20]=1[C:21]([N:13]1[CH2:14][CH:15]2[CH:11]([CH2:10][N:9]([C:4]3[N:5]=[C:6]([CH3:8])[CH:7]=[C:2]([CH3:1])[N:3]=3)[CH2:16]2)[CH2:12]1)=[O:22]

Participants

3

Reactant 2

HCID 151092,6-Dimethoxybenzoic AcidHCID 662108752-(4,6-Dimethylpyrimidin-2-yl)octahydropyrrolo[3,4-c]pyrrole

Product 1

HCID 67116470HCID 67116470, compound

Procedure

The title compound was prepared in a manner analogous to Example 15 utilizing in a manner analogous to Example 15, utilizing Intermediate 23 and 2,6-dimethoxybenzoic acid. MS (ESI) mass calcd. C21H26N4O3, 382.47; m/z found 383.1 [M+H]+. 1H NMR (CD3OD): 7.38 (t, J=8.4 Hz, 1H), 6.81 (s, 1H), 6.81-6.70 (m, 2H), 4.04-3.89 (m, 3H), 3.84 (s, 3H), 3.79 (s, 3H), 3.76-3.55 (m, 4H), 3.27-3.13 (m, 3H), 2.53 (s, 6H).

Sources & evidence

ORD record
ord-0d93eb5feab8428db3266af166701328
Source dataset
uspto-grants-2014_02
Patent number
US08653263B2

Reaction notes

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