HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 244049Generated: October 29, 2026
HCID 67116320, compound → HCID 69938983, compound
https://huagongshe.com/reaction/244049
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | HCID 67116320 | HCID 67116320 | — |
| Reactant | HCID 67116403 | HCID 67116403 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | HCID 69938983 | HCID 69938983 | — |
Reaction Steps
The title compound was prepared in a manner analogous to Example 367 substituting (5-(4,6-dimethylpyrimidin-2-yl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)(4-fluoro-2-iodophenyl)methanone for (5-(4,6-dimethylpyrimidin-2-yl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)(3-fluoro-2-iodophenyl)methanone, with the addition of catalytic CuI, substituting dioxane for DME, heating 130° C. in microwave for 60 min. The reaction was filtered through celite, rinsed with EtOAc and then concentrated and purified on RP agilent HPLC and fractions lyophilized. MS (ESI) mass calcd. for C24H24FN5O, 417.20; m/z found, 418.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08653263B2 |
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| Source dataset | uspto-grants-2014_02 |
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| ORD ID | ord-9f82929f6a4a4225b0ac30609389e5b1 |
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| Source note | uspto-grants-2014_02 |
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