6-Chloro-N,N,2-trimethyl-4-pyrimidinamine → (5-(6-(Dimethylamino)-2-methylpyrimidin-4-yl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)(4-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone

HRID 244056Notes

Reaction equation

HRID 244056 reaction equation
[CH2:1]1[CH:5]2[CH2:6][NH:7][CH2:8][CH:4]2[CH2:3][N:2]1[C:9]([C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][C:12]=1[N:19]1[N:23]=[CH:22][CH:21]=[N:20]1)=[O:10].Cl[C:25]1[N:30]=[C:29]([CH3:31])[N:28]=[C:27]([N:32]([CH3:34])[CH3:33])[CH:26]=1>>[CH3:33][N:32]([CH3:34])[C:27]1[N:28]=[C:29]([CH3:31])[N:30]=[C:25]([N:7]2[CH2:6][CH:5]3[CH2:1][N:2]([C:9]([C:11]4[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][C:12]=4[N:19]4[N:20]=[CH:21][CH:22]=[N:23]4)=[O:10])[CH2:3][CH:4]3[CH2:8]2)[CH:26]=1

Participants

3

Reactant 2

HCID 407870156-Chloro-N,N,2-trimethyl-4-pyrimidinamineHCID 67116159(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)(4-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone

Product 1

HCID 67117234(5-(6-(Dimethylamino)-2-methylpyrimidin-4-yl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)(4-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone

Procedure

The title compound was prepared utilizing (hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)(4-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone (Example 288, product from Step B) and 6-chloro-N,N,2-trimethylpyrimidin-4-amine. MS (ESI) mass calcd. C23H28N8O2, 448.52; m/z found 449.2 [M+H]+.

Sources & evidence

ORD record
ord-d5af4693cbb440eda7caccf612f1d7f5
Source dataset
uspto-grants-2014_02
Patent number
US08653263B2

Reaction notes

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