反应详情

Trans-1,2-bis(phenylsulfonyl)ethylene (1.37 g, 4.45 mmol) was added to a solution of the compound obtained in Step (12) in toluene, and air in a vessel containing the mixture was replaced with nitrogen. After having been refluxed for 8 hours, the mixture was concentrated under reduced pressure. The resultant reaction product was purified by silica gel chromatography (50% EtOAc/Hexane), whereby 10,11-bis(phenylsulfonyl)-4,4-dimethyl-3,5-dioxa-tricyclo[5.2.2.02.6]undec-8-ene was obtained (2.0 g, 98%).

1. additioncontaining the mixture
2. temperatureAfter having been refluxed for 8 hours
3. concentrationthe mixture was concentrated under reduced pressure
4. customThe resultant reaction product
5. customwas purified by silica gel chromatography (50% EtOAc/Hexane)