5-Chloro-4-methylindolin-2-one → 5-Chloro-3-(6-methoxybiphenyl-3-ylmethylene)-4-methyl-1,3-dihydroindol-2-one

HRID 24431Notes

Reaction equation

HRID 24431 reaction equation
[CH3:1][O:2][C:3]1[CH:10]=[CH:9][C:6]([CH:7]=O)=[CH:5][C:4]=1[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.[CH3:17][C:18]1[C:26]([Cl:27])=[CH:25][CH:24]=[C:23]2[C:19]=1[CH2:20][C:21](=[O:28])[NH:22]2>>[Cl:27][C:26]1[C:18]([CH3:17])=[C:19]2[C:23](=[CH:24][CH:25]=1)[NH:22][C:21](=[O:28])[C:20]2=[CH:7][C:6]1[CH:5]=[C:4]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:3]([O:2][CH3:1])=[CH:10][CH:9]=1

Participants

3

Reactant 2

HCID 103133885-Chloro-4-methylindolin-2-oneHCID 223912176-Methoxybiphenyl-3-carbaldehyde

Product 1

HCID 540498505-Chloro-3-(6-methoxybiphenyl-3-ylmethylene)-4-methyl-1,3-dihydroindol-2-one

Procedure

4-Methoxy-3-phenylbenzaldehyde was condensed with 4-methyl-5-chloro-2-oxindole to give 0.3 g of 5-chloro-3-(6-methoxybiphenyl-3-ylmethylene)-4-methyl-1,3-dihydroindol-2-one as a yellow-orange solid.

Sources & evidence

ORD record
ord-32e4fd04edd94e6198fcff43e3feebfc
Source dataset
uspto-grants-2005_02
Patent number
US06855730B2

Reaction notes

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