Methanol → HCID 58241680, compound

HRID 244326Notes

Reaction equation

HRID 244326 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[C:4](F)[C:3]=1[I:12].[CH3:13][O-:14].[Na+].[CH3:16][OH:17]>>[I:12][C:3]1[C:4]([O:14][CH3:13])=[C:5]([N+:8]([O-:10])=[O:9])[CH:6]=[CH:7][C:2]=1[O:17][CH3:16]

Participants

4

Reactant 3

HCID 887MethanolHCID 10942334Sodium MethoxideHCID 582416821,3-difluoro-2-iodo-4-nitrobenzene

Product 1

HCID 58241680HCID 58241680, compound

Procedure

1,3-Difluoro-2-iodo-4-nitrobenzene (5.0 g, 17.5 mmol) was dissolved in 50 ml of methanol, and NaOMe (3.79 g, 70.1 mmol) was added. The solution was heated under reflux for 16 h. After concentration, the residue was chromatographed on silica gel using petroleum ether/ethyl acetate. This gave 2-iodo-1,3-dimethoxy-4-nitrobenzene (3 g) as a yellowish powder.

Workup

  1. temperatureThe solution was heated
  2. temperatureunder reflux for 16 h
  3. concentrationAfter concentration
  4. customthe residue was chromatographed on silica gel

Sources & evidence

ORD record
ord-0c6fb4f4265c412494ee9877da64758b
Source dataset
uspto-grants-2014_02
Patent number
US08658569B2

Reaction notes

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