Boron tribromide → HCID 52912206, compound

Participants

Reaction Steps

At −78° C., 1N BBr3 in CH2Cl2 (1.5 ml, 1.5 mmol) was added to 6,8-dimethoxy-7-o-tolylquinoline (0.10 g, 0.36 mmol) in CH2Cl2 (5 ml), and the mixture was warmed to room temperature and stirred for 6 h. The solution was poured into ice-water and neutralized with saturated NaHCO3 solution. The mixture was extracted with ethyl acetate, and the organic phase was dried with Na2SO4. Purification of the residue by HPLC gave 6,8-dihydroxy-7-o-tolylquinoline (7 mg) as a white powder.

Provenance & Evidence