3,5-Diisopropyl-4-methoxybenzaldehyde → 3-[3-(3,5-diisopropyl-4-methoxybenzylidene)-2-oxo-2,3-dihydro-1H-indol-5-yl]-propionic acid

HRID 24436Notes

Reaction equation

HRID 24436 reaction equation
[CH:1]([C:4]1[CH:5]=[C:6]([CH:9]=[C:10]([CH:14]([CH3:16])[CH3:15])[C:11]=1[O:12][CH3:13])[CH:7]=O)([CH3:3])[CH3:2].[C:17]([CH2:20][CH2:21][C:22]1[CH:23]=[C:24]2[C:28](=[CH:29][CH:30]=1)[NH:27][C:26](=[O:31])[CH2:25]2)([OH:19])=[O:18]>>[CH:1]([C:4]1[CH:5]=[C:6]([CH:9]=[C:10]([CH:14]([CH3:16])[CH3:15])[C:11]=1[O:12][CH3:13])[CH:7]=[C:25]1[C:24]2[C:28](=[CH:29][CH:30]=[C:22]([CH2:21][CH2:20][C:17]([OH:19])=[O:18])[CH:23]=2)[NH:27][C:26]1=[O:31])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 105850253,5-Diisopropyl-4-methoxybenzaldehydeHCID 219257025-(2-Carboxyethyl)-2-oxindole

Product 1

HCID 697633653-[3-(3,5-diisopropyl-4-methoxybenzylidene)-2-oxo-2,3-dihydro-1H-indol-5-yl]-propionic acid

Procedure

3,5-Diisopropyl-4-methoxybenzaldehyde was condensed with 5-(2-carboxyethyl)-2-oxindole to give 0.35 g of 3-[3-(3,5-diisopropyl-4-methoxybenzylidene)-2-oxo-2,3-dihydro-1H-indol-5-yl]-propionic acid as a yellow-orange solid.

Sources & evidence

ORD record
ord-3713361e6bba447294ecd9137fb2bfb8
Source dataset
uspto-grants-2005_02
Patent number
US06855730B2

Reaction notes

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