Water → HCID 67512779, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of methyl 4-hydroxy-2-methyl-5-nitrobenzoate (6.3 g) in N,N-dimethyl-formamide (150 ml) were added at room temperature 18-crown-6 (79 mg) and potassium carbonate (8.3 g), and the mixture was stirred at 80° C. for one hour. The mixture was cooled to room temperature, and to the reaction solution were added water and ethyl acetate, and the mixture was extracted with ethyl acetate. The organic layer was dried over sodium sulfate, filtered and concentrated under reduced pressure to give the title compound (7.5 g).

Provenance & Evidence