Dimethylformamide → HCID 49872513, compound

Participants

Reaction Steps

To N-isopropyl-2,2-dimethyl-3-oxo-N-[(3R)-piperidin-3-yl]-4-[2-(propionylamino)-ethyl]-7-(trifluoromethyl)-3,4-dihydro-2H-1,4-benzoxazine-6-carboxamide hydrochloride (1.0 g) were added the compound of Reference Example 8 (344 mg), potassium carbonate (45 mg) and DMF (30 ml), and the mixture was stirred at room temperature overnight. After the reaction was completed, water was added to the reaction solution, and the mixture was extracted with ethyl acetate. The ethyl acetate solution was washed with water and aqueous sodium chloride solution, dried over magnesium sulfate, filtered and concentrated. The obtained residue was purified by column chromatography (hexane:ethyl acetate=1:2) to give the title compound (300 mg) as white amorphous.

Provenance & Evidence