Hydrazine hydrate (1:1) → HCID 86673686, compound

Participants

Reaction Steps

Hydrazine hydrate (0.17 g) is added to a solution of 0.87 g 4-(4-ethynylphenyl)-5-hydroxy-5-methyl-3-(2,4,6-trifluorophenyl)-5H-furan-2-one in 5 ml of 1-butanol and this mixture is heated for 4 h to 120° C. The reaction mixture is evaporated under reduced pressure and the residue is purified by chromatography on silica gel, using a mixture of toluene/ethyl acetate 5:1 as eluent to obtain 5-(4-ethynylphenyl)-6-methyl-4-(2,4,6-trifluorophenyl)-2H-pyridazin-3-one (Compound No. 1) as colourless crystals, m.p. 252-254° C.

Provenance & Evidence