Tetrahydrofuran → HCID 86673687, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-chloro-5-(4-ethynylphenyl)-6-methyl-4-(2,4,6-trifluorophenyl)pyridazine (Compound No. 2, 1.0 g), sodium methoxide (30% solution in methanol, 1.78 g) and 20 ml of tetrahydrofuran is heated to 55° C. for 2 h. Subsequently the reaction mixture is cooled, diluted with water and extracted with ethyl acetate. The combined organic layer is washed with water and brine, dried over sodium sulfate and evaporated under reduced pressure. The residue is purified by chromatography on silica gel, using a mixture of heptane/ethyl acetate 2:1 as eluent to obtain 4-(2,6-difluoro-4-methoxyphenyl)-5-(4-ethynylphenyl)-3-methoxy-6-methylpyridazine (Compound No. 4) as colourless crystals, m.p. 192-193° C.

Provenance & Evidence