Triethylsilane → 5-Butyl-2-oxindole

HRID 24439Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 24439
C([SiH](CC)CC)C.[C:8]([C:13]1[CH:14]=[C:15]2[C:19](=[CH:20][CH:21]=1)[NH:18][C:17](=[O:22])[CH2:16]2)(=O)[CH2:9][CH2:10][CH3:11]>FC(F)(F)C(O)=O>[CH2:8]([C:13]1[CH:14]=[C:15]2[C:19](=[CH:20][CH:21]=1)[NH:18][C:17](=[O:22])[CH2:16]2)[CH2:9][CH2:10][CH3:11]

Komponenten

4

Edukt 2

HCID 12052TriethylsilaneHCID 235593785-Butyryl-2-indolinone

Produkt 1

HCID 102197495-Butyl-2-oxindoleAusbeute 91,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6422Trifluoroacetic acidLösungsmittel

Versuchsvorschrift

Triethylsilane (2.3 g) was added to 2 g of 5-butanoyl-2-oxindole in 20 ml of trifluoroacetic acid at room temperature and the solution stirred for 3 hours. The reaction was poured into ice water to give a red oil which solidified after standing. The solid was collected by vacuum filtration, washed with water and hexane and dried to give 1.7 g (91% yield) of 5-butyl-2-oxindole as an off-white solid.

Aufarbeitung

  1. customto give a red oil which
  2. filtrationThe solid was collected by vacuum filtration
  3. washwashed with water and hexane
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-074aec7c2c6243f1903ab4dd29bfe215
Quelldatensatz
uspto-grants-2005_02
Patentnummer
US06855730B2

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