反应详情

温度

125 °C

A mixture of 2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-(5-methyl-6-methoxypyridin-3-yl)ethanol (0.679 mmol) and pyridinium hydrochloride (6.79 mmol) was warmed at 125° C. in a sealed tube for 20 minutes, cooled to room temperature and diluted with ether and water. The organic layer was washed with brine and dried over magnesium sulfate. The volatiles were removed in vacuo and the residue triturated with petroleum ether to provide the title compound.

1. temperaturecooled to room temperature
2. washThe organic layer was washed with brine
3. dry with materialdried over magnesium sulfate
4. customThe volatiles were removed in vacuo
5. customthe residue triturated with petroleum ether