反应详情

温度

100 °C

A mixture of 2,2,2-trifluoro-1-(1H-indazol-5-yl)-1-(1-methyl-1H-indol-3-yl)ethanol (0.122 mmol) and cyclobutanecarbonyl chloride (0.159 mmol) in 1 mL pyridine was heated at 100° C. for 1.5 hours, cooled to room temperature and diluted with ether and water. The organic layer was washed with water and brine and dried over magnesium sulfate. The volatiles were removed in vacuo and the residue purified by flash silica gel chromatography using 25% ethyl acetate in hexanes. The product-rich fractions were concentrated in vacuo to afford 0.091 mmol of the title compound, m.p. 79° C.-81° C.

1. temperaturecooled to room temperature
2. washThe organic layer was washed with water and brine
3. dry with materialdried over magnesium sulfate
4. customThe volatiles were removed in vacuo
5. customthe residue purified by flash silica gel chromatography
6. concentrationThe product-rich fractions were concentrated in vacuo