反应详情

温度

100 °C

A mixture of 2,2,2-trifluoro-1-(1H-indazol-5-yl)-1-(1-methyl-1H-indol-3-yl)ethanol (0.162 mmol) and benzoyl chloride (0.324 mmol) in 1 mL pyridine was heated at 100° C. After 2 hours, the mixture was cooled to room temperature and diluted with ether and water. The organic layer was washed with aqueous HCl and brine and dried over magnesium sulfate. The volatiles were removed in vacuo and the residue purified by flash silica gel chromatography using 33% ethyl acetate in hexanes. The product-rich fractions were concentrated in vacuo to provide 0.093 mmol of the title compound, m.p. 102° C.-103° C.

1. temperaturethe mixture was cooled to room temperature
2. washThe organic layer was washed with aqueous HCl and brine
3. dry with materialdried over magnesium sulfate
4. customThe volatiles were removed in vacuo
5. customthe residue purified by flash silica gel chromatography
6. concentrationThe product-rich fractions were concentrated in vacuo