Allyl bromide → HCID 16726256, compound

Participants

Reaction Steps

To a room temperature solution of 10.0 g (51.0 mmol) of 6-bromoindole in DMF was added 1.4 g (58.0 mmol) of 60% NaH in mineral oil. Once evolution of hydrogen ceased, allyl bromide was added. After 2 hours, the reaction was quenched with water and was extracted with ethyl acetate. The combined organic layers were washed with brine, dried over sodium sulfate, and concentrated in vacuo to afford 11.8 g (98%) of 1-allyl-6-bromo-1H-indole. MS m/z 237.11 (MH+).

Provenance & Evidence