Tributylvinyltin → HCID 24957619, compound

Participants

Reaction Conditions

Reaction Steps

To a room temperature solution of 0.25 g (0.4 mmol) of 1-[6-bromo-1-(4-methoxybenzyl)-1H-indol-3-yl]-2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]ethanol in toluene was added 0.13 g (0.4 mmol) of tri-n-butyl(vinyl)tin. After 15 minutes, 3.0 mg of dichlorobis(triphenylphosphine)Pd (II) was added and the reaction was warmed to 100° C. and stirred overnight. The mixture was then cooled to room temperature, filtered through a pad of CELITE® filter aid, and concentrated in vacuo. The residue was purified by flash chromatography using ethyl acetate-hexanes (5-20% gradient) to afford 0.1 g (44%) of the title compound. MS m/z 572.6 (MH+).

Provenance & Evidence