Sodium periodate → HCID 59437244, compound

Participants

Reaction Steps

To a solution of 242 mg (0.51 mmol) of 1-(2,3-dihydroxypropyl)-4-{2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}-1H-pyrrole-2-carbonitrile in 6 mL of acetone and 3 mL of water was added 114 mg (0.53 mmol) of sodium periodate. After stirring overnight, the solids were filtered and rinsed with acetone. The acetone was then concentrated in vacuo and the residue was diluted with brine and extracted with EtOAc. The combined organic layers were dried, filtered, and concentrated in vacuo to afford 208 mg of 1-(2-oxoethyl)-4-{2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}-1H-pyrrole-2-carbonitrile which was used without further purification.

Provenance & Evidence