Triethylamine → HCID 51030061, compound

Participants

Reaction Conditions

Reaction Steps

(S)—N-(3-(2-methylpyridin-4-yl)-1H-indazol-5-yl)-3-(methylthio)pyrrolidine-3-carboxamide 6 (176 mg, 0.2 mmol) and 2-chloro-1-(1-(thiazol-2-yl)piperidin-4-yl)ethanone 5 (52 mg, 0.2 mmol) was mixed in DMF (2 mL) together with triethylamine (0.1 mL). The reaction mixture was heated at 45° C. for 3 hrs before concentrated to dryness in vacuo. The resulting crude was purified on silica gel column (eluting with 2% to 4% NH3/MeOH (2 N) in CH2Cl2) to yield 7 as a light yellow solid (89 mg, 77%). LCMS M+1=576.3 retention time=1.73 min.

Provenance & Evidence