反应详情

To a solution of the commercially available 4-bromoacetyl-benzonitrile (5 g, 22.32 mmol) in 150 mL of methanol was added sodium azide (1.74 g, 26.78 mmol) and the contents stirred at room temperature for 2 h. After removal of the solvent, the residue was treated with water (50 mL) and extracted with dichloromethane (3×50 mL). The combined organic layers were dried over MgSO4 and concentrated to give a yellow solid (3.90 g, 94%). This compound was used for the next step without any further purification.

1. customAfter removal of the solvent
2. additionthe residue was treated with water (50 mL)
3. extractionextracted with dichloromethane (3×50 mL)
4. dry with materialThe combined organic layers were dried over MgSO4
5. concentrationconcentrated