Triphenylphosphine → 4-[2-(2-Methyl-5-nitro-phenylamino)-oxazol-5-yl]-benzonitrile

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Reaction Steps

To a solution of 4-Azidoacetyl-benzonitrile (1.5 g, 8.06 mmol) in dioxane 25 mL was added 2-methyl-5-nitrophenyl isocyanate (1.43 mg, 8.06 mmol) (commercially available), and triphenylphosphine (2.11 g, 8.06 mmol). The reaction mixture was placed in an oil bath preheated to 100° C. and stirred for 30 min. After evaporation of the solvent under reduced pressure, the solid residue was recrystallized from ethanol to give the title compound as yellow micro crystals (1.16 g, 45%).

Provenance & Evidence