Hydrazine hydrate (1:1) → HCID 59818282, compound

Participants

Reaction Steps

A solution of (2-methyl-5-nitro-phenyl)-(5-pyridin-4-yl-oxazol-2-yl)-amine (1 g, 3.39 mmol) in ethanol (50 mL) was treated with 10% Pd/C (120 mg) and hydrazine hydrate (3.50 mL, 112.5 mmol) was added drop wise over 10 min. The reaction mixture was stirred at room temperature for 30 min and then refluxed for 2 h. The hot solution was filtered through a short pad of Celite, and the catalyst was washed with hot ethanol. The filtrates were concentrated under reduced vacuum to give the crude product. This was silica gel column chromatographed (dichloromethane/ethanol: 97/3). 720 mg (80%) of (2-methyl-5-amino-phenyl)-(5-pyridin-4-yl-oxazol-2-yl)-amine was obtained as pale yellow powder.

Provenance & Evidence