Sodium Hydroxide → HCID 58356323, compound

Participants

Reaction Conditions

Reaction Steps

A solution of ethyl 5-(1-methylethyl)-2-(4-morpholinylmethyl)-1,3-thiazole-4-carboxylate (77 mg) in methanol (5 ml) was treated with 2M sodium hydroxide solution (5 ml) and the mixture stirred at 20° C. for 18 h. The mixture was concentrated in vacuo and the residue taken up in water (3 ml). The pH was adjusted to pH 5-6 using 2M hydrochloric acid solution and extracted with DCM (10 ml), separated by hydrophobic frit and evaporated to give the title compound as a pale yellow gum (33 mg).

Provenance & Evidence