HCID 12609048, compound → HCID 58356436, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of methyl 5-[bis(methyloxy)methyl]-1H-pyrazole-3-carboxylate (20 g) in tert-butanol (250 ml) at 40° C. was added potassium tert-butoxide (28.1 g) and the mixture stirred at 50° C. for 45 h. The solution was evaporated under reduced pressure, diluted with water (150 ml) and extracted with ethyl acetate (4×100 ml). The combined organic extracts were dried over magnesium sulphate and evaporated under reduced pressure to give the title compound (18.6 g) as an oil.

Provenance & Evidence