Potassium bisulfate → HCID 58356383, compound

HRID 244627Notes

Reaction equation

HRID 244627 reaction equation
C[O:2][CH:3](OC)[C:4]1[NH:8][N:7]=[C:6]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH:5]=1.S(=O)(=O)(O)[O-].[K+]>CC(C)=O.O>[CH:3]([C:4]1[NH:8][N:7]=[C:6]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH:5]=1)=[O:2]

Participants

5

Reactant 2

HCID 516920Potassium bisulfateHCID 58356436HCID 58356436, compound

Product 1

HCID 58356383HCID 58356383, compoundYield 74.4%

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 962WaterSolvent

Procedure

To a solution of 1,1-dimethylethyl 5-[bis(methyloxy)methyl]-1H-pyrazole-3-carboxylate (18.6 g) in acetone (100 ml) was added 1M potassium bisulphate solution (200 ml) and the resultant suspension stirred at RT overnight. The mixture was diluted with water (200 ml), stirred for 10 min, filtered and the resultant solid washed sequentially with water, isopropanol and hexane and dried under high vacuum to give the title compound (11.2 g) as a solid.

Workup

  1. filtrationfiltered
  2. washthe resultant solid washed sequentially with water, isopropanol and hexane
  3. customdried under high vacuum

Sources & evidence

ORD record
ord-1ca069161ff342629d3bf2cd1a177f63
Source dataset
uspto-grants-2014_02
Patent number
US08658635B2

Reaction notes

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