反应详情

温度

60 °C

2M Sodium hydroxide solution (114 ml) was added to a solution of 4-bromo-2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine (16 g) in 1,4-dioxane (320 ml) and the reaction heated at 60° C. overnight. After cooling, the aqueous layer was separated and washed with ethyl acetate. The combined organics were washed with brine, dried over magnesium sulphate, filtered, and then evaporated to give title compound (10.1 g) as a cream coloured solid.

1. temperatureAfter cooling
2. customthe aqueous layer was separated
3. washwashed with ethyl acetate
4. washThe combined organics were washed with brine
5. dry with materialdried over magnesium sulphate
6. filtrationfiltered
7. customevaporated