反应详情

温度

80 °C

To 2-methyl-1,3-thiazole-4-carboxylic acid (1 g) was added thionyl chloride (5 ml). The mixture was heated at 80° C. for 8 h. Thionyl chloride (5 ml) was added and the mixture heated for 2 h at 80° C. Further thionyl chloride (5 ml) was added and the mixture heated for 2 h. The mixture was concentrated in vacuo and azeotroped with toluene to give the title compound (1.12 g) as a brown solid

1. temperaturethe mixture heated for 2 h at 80° C
2. temperaturethe mixture heated for 2 h
3. concentrationThe mixture was concentrated in vacuo
4. customazeotroped with toluene