Ethyl 2-(diethoxymethyl)thiazole-4-carboxylate → Ethyl 2-formyl-1,3-thiazole-4-carboxylate

Beteiligte Stoffe

Reaktionsschritte

A solution of ethyl 2-[bis(ethyloxy)methyl]-1,3-thiazole-4-carboxylate (455 mg) in 10% 1M hydrochloric acid in acetone (50 ml) was heated at reflux for 1 h. The mixture was concentrated in vacuo, taken up in DCM (20 ml) and washed with saturated sodium bicarbonate solution (10 ml). The organic layer was separated using a hydrophobic frit and evaporated to give the title compound (317 mg) as a yellow solid.

Herkunft & Nachweise