Sodium Hydroxide → HCID 58356330, compound

Participants

Reaction Steps

To a solution of ethyl 2-(1-methylethyl)-2H-1,2,3-triazole-4-carboxylate (670 mg) in methanol (6 ml) was added sodium hydroxide (4 ml) and the mixture was stirred at room temperature for 4 h. The methanol was removed in vacuo and water (10 ml) was added and the mixture neutralised (pH 5-6) by the addition of 2M hydrochloric acid. The aqueous layer was extracted with DCM, separated by hydrophobic frit and the organic layer evaporated in vacuo to give the title compound (455 mg) as a white solid.

Provenance & Evidence