反应详情

温度

20 °C

To a solution of methyl 5-(1-methylethyl)-1,3-thiazole-4-carboxylate (1.9 g) in methanol (20 ml) was added 2M sodium hydroxide (20 ml) and the mixture stirred at 20° C. for 18 h. The solvent was removed in vacuo and the residue taken up in water (20 ml) and acidified to pH=2 using 2M hydrochloric acid. The mixture was extracted with ethyl acetate (100 ml), dried over sodium sulphate and evaporated in vacuo to give the title compound (1.7 g) as a white solid.

1. customThe solvent was removed in vacuo
2. extractionThe mixture was extracted with ethyl acetate (100 ml)
3. dry with materialdried over sodium sulphate
4. customevaporated in vacuo