反应详情

温度

20 °C

To a solution of ethyl 1-(2-fluoroethyl)-1H-pyrazole-5-carboxylate (0.2 g) in methanol (5 ml) was added 2M sodium hydroxide (5 ml) and the mixture stirred at 20° C. for 18 h. The solvent was removed in vacuo and the residue dissolved in water (20 ml) and acidified to pH-4 using 2M hydrochloric acid then extracted with ethyl acetate (20 ml), dried over sodium sulphate and evaporated to give the title compound (0.132 g) as a white solid.

1. customThe solvent was removed in vacuo
2. dissolutionthe residue dissolved in water (20 ml)
3. extractionthen extracted with ethyl acetate (20 ml)
4. dry with materialdried over sodium sulphate
5. customevaporated