Sodium Hydroxide → 1-(2-Fluoroethyl)-1H-pyrazole-3-carboxylic acid

Participants

Reaction Conditions

Reaction Steps

To a solution of ethyl 1-(2-fluoroethyl)-1H-pyrazole-3-carboxylate (0.1 g) in methanol (5 ml) was added 2M sodium hydroxide (5 ml) and the mixture stirred at 20° C. for 18 h. The solvent was removed in vacuo and the residue dissolved in water (20 ml) and acidified to pH=4 using 2M hydrochloric acid then extracted with ethyl acetate (20 ml), dried over sodium sulphate and evaporated to give the title compound (16 mg) as a white solid.

Provenance & Evidence