Sodium Hydroxide → 5-(Propan-2-yl)-1,3-oxazole-4-carboxylic acid

Temperature

20 °C

To a solution of methyl 5-(1-methylethyl)-1,3-oxazole-4-carboxylate (0.55 g) in methanol (10 ml) was added sodium hydroxide (10 ml) and the mixture stirred at 20° C. for 18 h. The solvent was removed in vacuo and the residue dissolved in water (10 ml) then acidified using 2M hydrochloric acid. The mixture was concentrated until precipitation commenced when the mixture was extracted with ethyl acetate, dried over sodium sulphate and evaporated to give the title compound (0.45 g) as a yellow solid.

1. customThe solvent was removed in vacuo
2. dissolutionthe residue dissolved in water (10 ml)
3. concentrationThe mixture was concentrated until precipitation
4. extractionwas extracted with ethyl acetate
5. dry with materialdried over sodium sulphate
6. customevaporated

ORD record

ord-5d963c05c152423eaa2addfd5074c153

Source dataset

uspto-grants-2014_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08658635B2